Tissue Inhibitor of Metalloproteinase 2

Description: Biotechnologically produced protein called TIMP2 (tissue inhibitor of metalloproteinase 2) able to inhibit MMP-2 (matrix metalloproteinases 2) that degrade collagen in the skin. Clear, colorless liquid, pH 7-8. Soluble in water. CAS# 124861-55-8.

INCI Name: Tissue inhibitor of metalloproteinase 2.

Properties: Up to 100% collagen protection by potent inhibition of specific skin enzymes (metalloproteinases) that degrade tissue collagen, protects actively from sun damages of the skin & skin aging while maintaining the skin’s natural protein architecture, restores dermal tissue.

Use: Use in formulas as is, usual concentration 1-3 %, to be incorporated into the aqueous phase of a formula, can be processed cold or warm (up to 70oC, 158oF), compatible with up to 30% alcohol.

Application: Mid & longterm anti-aging treatments (creams & lotions), sun care & after-sun products.

More Information: MSDS, Fact Sheet, Sample Recipe, Article

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Ceramides

Ceramides are structural lipids and are located between skin cells in the connective tissue. They are also thought to play a considerable role in the water-holding potential of the stratum corneum. Ceramides are also a major skin cell component and are responsible for cell stability by forming a multilamellae architecture. Ceramide, ceramide 3, ceramide 6 II, ceramide 1 (available as ceramide complex and lacto-ceramide) have been clinically shown to be effective in preventing and improving dry and blemished skin.

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